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doi:10.1016/S0021-9150(00)00475-5

Even with low levels of exposure, chemicals in cigarette smoke increase the risk of cardiovascular illness, cancer, respiratory disease, and death (including Sudden infant death syndrome [SIDS]

It established the first sustained contact between the Americas and the rest of the world, and it created a network of trade routes and economic relationships that spanned the globe

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and Europe in 2006, and it is reported that they were marketed as a harm reduction device.[6] However, the US Food and Drug Administration explicitly states that no e-cigarette has been approved as a cessation device or authorized to make a modified risk claim and more research is needed to understand the potential risks and benefits these products may offer adults who use tobacco products.[7] K Jones et al