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As much as it was an insult to Layne, it was also just as much an illustration of how much MTVs focus had shifted in the years since Cobains death in 1994 a point at which alt-rock bands, including Seattle bands, were being featured a lot on MTVs rotations to the death of Layne Staley in 2002, by which time MTV had become almost entirely dominated by mainstream hip-hop or pop-chart music and any traces of indie, alternative or rock had almost entirely vanished

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In addition, human studies have demonstrated that CB agonists and VDCC ligands alleviate pain and anxiety and promote sleep, as described above, which are also effects produced by tiagabine (e.g., Flowers et al., 2006