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Examples of deficiencies that lead to an RTA include: if the submission does not pertain to a tobacco product, if it is not in English or does not contain complete English translations, if it is in an electronic format FDA cannot process, read, review, and archive, or if the submission does not include an environmental assessment or valid claim of categorical exclusion

doi: 10.1097/JTO.0b013e318288dc96

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The most significant decrease occurred among adults ages 25 to 44