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Mono-allelic DNA methylation within imprinted genes escapes the global erasure/re-establishment to preserve parent-of-origin expression (Popp et al., 2010) and the re-establishment of DNA methylation patterns is catalyzed mainly by de novo DNA methyltransferases, DNMT3A and DNMT3B ( FIGURE 1 The erasure/re-establishment of DNA methylation during early embryogenesis aids in the process of cell differentiation (Straussman et al., 2009)

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