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CS increased the expression of pro-inflammatory mediators IL - 8 , TNF - and matrix metalloproteinase 9 through HDAC1 depression in rat lungs and in macrophages, while knocking down HDAC1 increases the expression of these genes [37]

Taken together, understanding the contributions of immune and metabolic parameters to tumour development is crucial for improving the predictive value and therapeutic strategies for p53 mutant lung cancers

[28] Smoking has been also associated with oral conditions including dental caries, dental implant failures, premalignant lesions, and cancer

In recent years, evidence has suggested that epigenetic modification mechanisms can possibly explain the link between CS exposure and inflammation

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