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When someone stops consuming cannabis after regular or heavy consumption, they may experience withdrawal symptoms and feel the need to consume cannabis again to reduce symptoms (e.g., irritability, frustration, restlessness, trouble sleeping, depression or anxiety, cravings or changes in appetite, and weight loss)

15 While nicotine can cause vasoconstriction and thus contribute to tissue hypoxia, the hypoxic effects of nicotine are much shorter lasting than those of carbon monoxide

Smoking is responsible for more than 480,000 deaths per year in the country