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The OED has the earliest use of the misspelled obsidian as 1601

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Recon3D enables a three-dimensional view of gene variation in human metabolism

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The United States FDA classifies caffeine as a drug and food additive, widely used in various beverages, with a recommended maximum daily intake of 400mg

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Electronic Cigarette Use and Respiratory Symptoms in Adolescents, American Journal of Respiratory and Critical Care Medicine 195

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Even researchers have different views on it

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