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Smoking introduces carcinogens that damage stomach lining cells and worsen Helicobacter pylori infection effects, increasing cancer risk

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Moreover, microbiome-targeted therapies, including the use of antimicrobial peptides or specific bacteriophages, may provide more direct means of modulating microbial communities to reduce disease risk

They can include medications such as disulfiram, acamprosate, and naltrexone for alcohol use disorder, methadone, buprenorphine, and naltrexone for opioid use disorder, and nicotine replacement therapy, bupropion, and varenicline for nicotine dependence, among others