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If you are exposed to nicotine over a long period you produce more of the signal-disrupting chemicals and this desensitizes you, researcher Ines Ibanez-Tallon said

These nations experience higher vulnerability because tobacco use and second-hand smoke contribute significantly to cardiovascular diseases, accounting for 17% of CVD deaths worldwide
Barbouni A, Hadjichristodoulou C, Merakou K, Antoniadou E, Kourea K, Miloni E, Warren CW, Rahiotis G, Kremastinou J

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