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This spike dramatically increases the heart rate
The lipid bilayer then serves as a drug reservoir that maintains a continuous source of salmeterol that can access the beta 2 receptor via a lipid bilayer pathway, as well as release of salmeterol into the aqueous environment surrounding the beta-2 receptor, long after the initial bolus of inhaled drug has been eliminated from the extracellular environment (Anderson et al, 1994

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A dose-response trend was also present with increasing ORs observed for higher levels of smoking (1-9 cigarettes daily: OR = 1.05, 95% CI: 0.95, 1.17
