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Description
Rolling Your Own: Weighing the Advantages of Whole Leaf Tobacco vs

The species was first described from the upper Missouri River where it was cultivated by the Mandan and Arikara

Crit Rev Toxicol 1990

[223] US Department of Labor (DOL), Occupational Health and Safety Administration (OSHA), Agricultural Operations: Hazards and Controls, undated, (accessed December 11, 2013)

Humans need to eat to live, so there has to be some form of behavioral change
