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For wounds exceeding 5060 cm 2 , free flaps like latissimus dorsi provide versatile, well-vascularized coverage suitable for complex injuries with exposed bone, tendon, or hardware []

In contrast, a 2010 study by British Professor David Nutt and colleagues asked a panel of experts to score 20 drugs on 16 criteria nine related to the harms a drug could cause to an individual (including the risk of overdose and long-term health damage) and seven criteria relating to the harm caused to others (including accidents, crime and economic costs)

A combination of factors, really

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One factor is the effect that the nicotine in cigarettes has on your metabolism