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Potential mechanisms for this interaction include (1) cooperation between germline and somatic variants in different pathways to promote a clonal advantage 318 , (2) germline variants acting downstream of somatic variants to modulate clonal advantage (and vice versa), (3) germline variants promoting the formation of larger-scale somatic events such as chromosomal abnormalities 177 , and (4) germline variants (for example, in DNA repair pathways) contributing to clonal advantage, agnostic to the nature of the somatic mutation driving the clone

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It has not been linked to any cancer cases

Vedders eyes narrow, and he continues, Liebling (whom he married in 1994 and divorced in 2000) put up new fences around their Seattle house and enlisted twenty-four-hour security, even demanding that Pearl Jams then-label, Epic Records, help pay for it: If you want records out of me, youre going to have to help pay for security to protect your guy right now. Still, one day, he reveals, This woman drove her car at fifty miles per hour into the wall of my house and almost killed herself. Fear of the stalker which he chronicled in the track Lukin, from 1996s No Code (I find my wife, I call the cops, this days works never done/The last I heard that freak was purchasing a fucking gun) made it hard for Vedder to leave the house and contributed to his reputation as an angry recluse