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46 Rheumatoid arthritis (RA) is an autoimmune disease with polarization disorder toward Th1 and Th2 that produces proinflammatory cytokines such as IL-1, IL-6, IL-17, TNF-, IFN- and IL-8 and, as a result, causes an inflammatory state in the body

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Jee SH, Samet JM, Ohrr H, Kim JH, Kim IS: Smoking and cancer risk in Korean men and women

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The sense of relaxation and calm from smoking is partly generated by dopamine release in the brain which rewards you with a feel-good boost or sense of relief from the tension of withdrawal each time you smoke