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In addition, to facilitate regulatory acceptance, applicants should clearly describe their NAM, including the context in which the NAM will be used (e.g., for screening/prioritization or quantitative risk assessment), the relevance of the model system to human biology and mechanisms of toxicity, and how the NAM informs the toxicological issue/gap

NeuroImage doi:10.1016/j.neuroimage.2019.116158

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Its far too easy to balls them up, leaving it too long and ending up with a hard-boiled disaster