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This results in the release of a large amount of cellular contents into the extracellular matrix, triggering a strong inflammatory response and promoting a feedback loop between cellular damage and inflammation, thereby exacerbating tissue damage (Quan et al., 2024)

Importantly, control cells, including BEAS-2B and human lung organoids, were passaged in parallel under the same culture conditions and duration as the WCSE-exposed cells, which allowed us to compare adaptive changes arising specifically from chronic smoke exposure rather than from prolonged culture alone
Data collection occurred during the COVID-19 pandemic, and as such, some findings may not generalize to the post-COVID period

Because most PARPs have been found to exhibit only mono ADP-ribosyltransferase activities, a new nomenclature was proposed for enzymes catalyzing ADP-ribosylation: A family of mono ADP-ribosyltransferases with homology to bacterial diphteria toxins was named ARTD, while enzymes with either mono or poly ADP-ribosyltransferase activities and related to C2 and C3 clostridial toxins were included in the ARTC family (7, 8)
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