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Notably, when we consider Level-2 heterogeneity in period and cohort effects, Level-1 effects reported in prior published reports still hold

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And this is the only significant downside and the reason why I rate it so low

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The IARC classifies chemicals, air pollution, pharmaceuticals and behaviors, all of which are referred to as agents, into four categories based on whether existing scientific research shows the agent in question is capable of causing cancer in humans