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10.1371/journal.pmed.1002713 [DOI] [PMC free article] [PubMed] [Google Scholar] 60.Augustson E, Engelgau MM, Zhang S, et al

Classical culture systems with human small airway cells are unable to reproduce the breathing motions of the lung and commonly used laboratory animals cannot reflect human smoking because they breathe through their noses, and their inflammatory responses differ from those in humans

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