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It is an interesting fact that in the largest coordinated enforcement effort in the FDAs history, the agency issued more than 1,300 warning letters and fines to retailers that illegally sold JUUL and other electronic cigarettes brands to minors.102 This phenomenon shows that there are substantial challenges involving the legal regulation and on-market monitoring of these products

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85 These methods may help determine whether cigarette or EC exposure is linked to macrophage-rich inflammatory niches, altered fibroblast-immune interactions, or exposure-specific synovial programs that cannot be detected in bulk analysis

Smad3 mediates cigarette smoke extract (CSE) induction of VEGF release by human fetal lung fibroblasts