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Clinical therapeutic effects and challenges of GLP-1 receptor agonists The primary GLP-1RAs used worldwide as anti-obesity drugs are liraglutide (Saxenda, Novo Nordisk) as a once-daily subcutaneous injection and semaglutide (Wegovy, Novo Nordisk) as a once-weekly subcutaneous injection

10.1111/j.1742-1241.2009.02143.x 29 CharbonnelB.SchweizerA.DejagerS

Once acute pancreatitis has been confirmed in a patient taking a GLP-1 receptor agonist, the medication should not be restarted

Those brought on by dehydration may linger longer and come with additional symptoms such as dizziness or a dry mouth

GLP-1 is extremely temperature-sensitive: extreme heat or freezing conditions can ruin it completely, and constant temperature swings can weaken its effectiveness