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Description
NICE was created by the UK government in 1999, initially as the National Institute for Clinical Excellence

When compared to other strategies, GLP-1R agonists occupy an intermediate position, more effective than lifestyle or other pharmacological interventions, but less invasive than bariatric surgery, underscoring their unique therapeutic niche
This could potentially be run as a single study with the induction trial proposed above, however we would suggest that results be published in two phases so that the very short-term induction data is not held back while waiting for success rate data
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