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In addition to the cAMP axis, incretin hormone receptor activation can engage the extracellular signal-regulated kinase (ERK1/2) and phosphoinositide 3-kinase (PI3K)/Akt routes, pathways integral to cell survival, proliferation, and receptor cross-talk [22], further potentiating the beneficial effects of incretin agonists on -cell health and peripheral insulin sensitivity

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doi: 10.1186/1471-230X-9-6 19 ClarkeG.McKernanD

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