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Epidemiology Peak onset: 1535 years Slight female predominance Higher prevalence in smokers Etiology & Pathogenesis Multifactorial: genetic susceptibility (NOD2), immune dysregulation, environmental triggers Transmural inflammation fistulas, strictures, abscesses Discontinuous involvement (skip areas) Common Sites Terminal ileum (most common) Ileocolonic Colonic Perianal disease common Clinical Features Intestinal: Chronic diarrhea (often non-bloody) Abdominal pain (classically RLQ) Weight loss Malabsorption Intestinal obstruction (strictures) Perianal disease: Fistulas Abscesses Anal fissures Extra-intestinal Manifestations Joints: Peripheral arthritis, ankylosing spondylitis Skin: Erythema nodosum Eyes: Uveitis, episcleritis Hepatobiliary: Fatty liver, gallstones Renal: Oxalate stones Diagnosis Ileocolonoscopy with biopsy gold standard Cobblestone mucosa, aphthous ulcers, skip lesions Histology: Non-caseating granulomas (not always present) Imaging: MR enterography / CT enterography for extent & complications Labs: CRP/ESR, anemia, hypoalbuminemia Exclude infection Management Induction of remission: Corticosteroids (moderatesevere) Budesonide (ileocecal disease) Maintenance: Azathioprine / Methotrexate Biologics: Anti-TNF (infliximab), anti-integrin, anti-IL-12/23 Surgery: For complications (strictures, fistulas, abscesses) Not curative disease often recurs Complications Strictures obstruction Fistulas (entero-enteric, entero-vesical, perianal) Abscesses Malnutrition Increased risk of colorectal cancer Transmural inflammation Skip lesions Any part of GI tract Smoking worsens disease Surgery cure To view or add a comment, sign in Esophageal Cancer Definition: Malignant tumor of the esophagus, the muscular tube connecting the pharynx to the stomach

Los pacientes con diabetes y retinopata diabtica preexistente deben ser monitoreados cuidadosamente, ya que la mejora rpida del control glucmico puede empeorar temporalmente esta condicin

[18] [19] The mechanism of action involves binding to receptors in the pancreas, brain, and gastrointestinal tract, which influences insulin secretion and appetite regulation