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Semaglutide Impacts Proteomic Signatures Related to Dementia Risk in the SELECT Cardiovascular Outcomes Trial

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Clinical Practice Research Datalink, we emulated a target trial through an active-comparator new-user cohort design, comparing GLP-1 receptor agonists to SGLT-2 inhibitors

This review highlights key clinical considerations across reproductive stages, emphasizes the primacy of human exposure data where available, and identifies critical evidence gaps requiring future prospective study.

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