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GLP-1 RAs may benefit patients with this obstructive sleep apnea syndrome by weight loss, reducing systemic inflammation, improving metabolic dysregulation, and reversing endothelial dysfunction [9]

Summary of revisions: Standards of Care in Diabetes 2026

Interestingly, GLP-1RAs have been reported to activate the metabolism of brown fat and increase the energy expenditure in rodents through exercise activities independent of the sympathetic nervous system pathway (3)

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The PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes trial is a multicenter study evaluating GLP-1 RAs versus SGLT2i for both primary and secondary prevention of ASCVD in patients with T2DM [62]