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10.1016/j.bbrc.2020.03.035 [DOI] [PubMed] [Google Scholar] Karaman I., Gunay A
Aim for a modest caloric deficit
Direct Titration Protocol When moving from a peptide like Tirzepatide to Retatrutide, researchers typically look at two models: The Washout Method: Discontinuing the dual-agonist entirely, allowing the body to clear the peptide over 2-3 weeks, and then starting the triple-agonist at the absolute lowest baseline dose
They were very limited in efficacy and safety
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