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GLP-1RA were initially developed to treat type 2 diabetes patients, in whom the effects upon glycemia and, moreover, weight loss, especially with long-acting GLP-1RA, were evident

Novo Nordisk's GLP-1 pill gains FDA nod to reduce risk of cardiovascular events

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Edit to note that the chart does not include older medications such as diethylpropion, phentermine and phendimetrazine (still available) and sibutramine (no longer available)