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Semaglutide and naltrexone can be used concurrently and are not contraindicated, but require baseline liver function tests and careful monitoring for GI side effects

Meanwhile, mindfulness's effect on the DMN is direct: it is a practice specifically aimed at noticing and letting go of wandering thoughts, thereby deactivating the DMN

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The first GLP-1R agonists to enter clinical use were peptide analogs and derivatives, as exemplified by exendin-4 (Eng et al., 2014), liraglutide, albiglutide, and dulaglutide (Table 3)

They serve different purposes