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The difference lies in the prescribing indication, not the titration approach

Whilst one study on L cell-like lines did not support a direct effect of metformin on L cells to mediate this effect [60], a more recent study has reported a direct effect of metformin on these cells, where an increase in the expression of the gene encoding proglucagon by metformin is mediated via a -cateninTCF7L2-mediated mechanism [63, 65]

Patients interested in learning more can also explore our Weight Loss Treatments page for additional information about semaglutide, tirzepatide, and medically supervised care

Essential Weight Loss Tips While on GLP-1 Medications 1

BMI thresholds still exist because clinical trials primarily studied patients meeting specific BMI requirements, and FDA indications and insurance policies are generally based on those populations