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Accordingly, people with type 2 diabetes, cardiovascular disease, heart failure, or chronic kidney disease should be treated appropriately with an SGLT-2 inhibitor or GLP-1RA, even because more adults with type 2 diabetes in the US have suboptimal glycemic control now compared to 10 years ago, associated with a resurgence in vascular diabetic complications [32]

Besides, the protective and therapeutic effects of GLP-1RAs on the central nervous system have now been confirmed by several studies (25, 26)

Approved GLP-1 medications undergo rigorous bioavailability testing to ensure therapeutic drug levels reach systemic circulation

Literature on this topic is too large to summarise comprehensively, but it suffices to say that GLP1R agonists are capable of increasing the activity of neurons that promote satiety, while simultaneously decreasing the activity of neurons that promote hunger

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