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Description
Both native glucagon and GCGR-GLP-1R co-agonists acutely increase energy expenditure in short-term studies over hours to days in humans [[54], [55], [56], [57]]
Saxagliptin is administered once daily due to its active metabolite, which retains half the potency of saxagliptin
Thomas, M.K., et al
(2012a)
Taken together, the available evidence supports the hypothesis that GLP-1R agonists may attenuate select components of opioid reinforcement, relapse, and withdrawal
