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These programs can be effective for some but may not address underlying metabolic issues that make weight loss challenging

78 A statistical analysis that included nine randomized controlled trials, involving a total of 591 women with PCOS, also reported finding omega-3 fatty acid supplementation improved insulin sensitivity, lowered total cholesterol and triglyceride levels, and raised levels of adiponectin (a signaling peptide primarily produced by fat tissue that improves insulin sensitivity and has anti-inflammatory properties)

The American Diabetes Associations 2026 Standards of Care recommends both GLP-1 receptor agonists and SGLT2 inhibitors for patients with type 2 diabetes and established or high risk of cardiovascular disease

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In practice, this effect appears to be clinically minor for metformin because metformin is primarily absorbed in the small intestine rather than the stomach