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Additionally, impaired leptin regulation in the liver disrupts satiety signals, driving overeating and creating a vicious cycle

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FDA-approved medications for Cushing's syndrome include osilodrostat (Isturisa), levoketoconazole (Recorlev), pasireotide (Signifor), and mifepristone (Korlym)the latter specifically indicated for hyperglycemia secondary to Cushing's syndrome

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The term triplet * refer to a high glucose (25 mM) level with 10 mM L-glutamine and 5 mM sodium butyrate

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E.LakshmananM.et al (2020)

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