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Even mild dehydration (2 percent of body weight) can reduce exercise performance by 10 to 20 percent and significantly delay recovery

In the GLP-1 RA group, 33 participants were subsequently newly diagnosed with heart failure, compared with 15 in the SGLT2i group (RR 0.44 [95% CI 0.23, 0.83] p =0.0092)

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Cost also contributed to the growth of compounded GLP-1 programs
Impact of weight loss on testosterone levels: a review of BMI and testosterone