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It was found that more patients in the LIR group than the placebo group maintained their weight loss by 5%, which indicated that LIR 3.0 mg/d is expected to improve the maintenance of weight loss (93)

Nausea, vomiting and diarrhoea are some of the most common side effects

Furthermore, the weight loss induced by tirzepatide appears to be primarily due to a greater reduction in fat mass compared to metabolically active lean mass, resulting in a favorable redistribution of abdominal ectopic adipose tissue and a marked reduction in waist circumference and intrahepatic fat [54]

Cardiovascular and renal outcomes with empagliflozin in heart failure

Diabetes Care, 28 , 21302135