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Clinical studies with T2D patients have demonstrated efficacy of small-molecule and peptide-based antagonists in decreasing fasting/post-prandial glucose levels and HbA1c without severe adverse effects or probability of hypoglycemia [31]

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Several key differences exist between the products in terms of molecular structure, pharmacokinetics, dose, administration, storage as well as efficacy, tolerability, and patient satisfaction

63.8%), lower rates of chronic kidney disease (10.3% vs

Several studies suggest that similar to lipids, reductions in food intake via intestinal protein in rodents are due to CCK release and subsequent activation of VANs, as (1) intestinal protein infusion increases CCK in rodents and humans 188,189