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As a result, for many, Mounjaro can be a supportive tool for significant weight loss: In the SURMOUNT-3 phase 3 clinical trial on tirzepatide (Mounjaro) for obesity and overweight, participants who took the drug and made lifestyle changes for 72 weeks, following 12 weeks of intensive lifestyle changes, lost on average 24.3% to 26.6% of their body weight

At a consistent loss rate of one to one and a half pounds per week during peak months, most patients in this range reach 30 pounds somewhere between months five and seven on semaglutide, or months four and six on tirzepatide