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As human GLP-1 is able to bind with high affinity and potently activate the platypus GLP-1R (Fig

Graphical Abstract Keywords NAFLD, MASLD, Clinical trial, Medication, Hypoglycemic agents, Intermediary metabolism Introduction In 2020, a group of experts aimed to integrate the understanding of patient heterogeneity and more accurately highlight disease pathogenesis captured under the acronym non-alcoholic fatty liver disease (NAFLD)