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Rationale : Nonalcoholic steatohepatitis (NASH) is a common disease that is associated with increased morbidity and mortality, with limited treatment options

5.6 Necrotizing Fasciitis of the Perineum (Fourniers Gangrene) Reports of necrotizing fasciitis of the perineum (Fourniers Gangrene), a rare but serious and life-threatening necrotizing infection requiring urgent surgical intervention, have been identified in postmarketing surveillance in patients with diabetes mellitus receiving SGLT2 inhibitors, including dapagliflozin

Dave Kisor from Manchester University College of Pharmacy (Fort Wayne, IN)

Subtherapeutic dosing may result in persistently elevated blood glucose levels, increasing the risk of both acute and long-term complications

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