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For uninsured patients, a single-dose pen often costs $300$500 out-of-pocket, making long-term therapy a significant financial burden

No significant effects on acyl-ghrelin or leptin were found (Fig

Significant or rapid weight loss can further increase the risk of gallstones

Graphical Abstract Keywords NAFLD, MASLD, Clinical trial, Medication, Hypoglycemic agents, Intermediary metabolism Introduction In 2020, a group of experts aimed to integrate the understanding of patient heterogeneity and more accurately highlight disease pathogenesis captured under the acronym non-alcoholic fatty liver disease (NAFLD)