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Raoux 1

Semaglutide is a versatile medication with multiple beneficial effects

The drug label does not authorize use in pediatric patients for diabetes management, though off-label pediatric use may occur under careful medical supervision in select cases of type 2 diabetes in adolescents

Most patients who succeed do so at Level 2 or Level 3, not Level 1

Data suggest that activation of GIP-R decreases inflammation in adipose tissue and cytokines levels (such as IL-6) and promotes the rise of serum adiponectin levels, a cytokine with anti-inflammatory effects and beneficial effects on diabetic nephropathy, which can explain potential beneficial effects on kidneys (even if GIP-R are not present) (47)