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Plasminogen activator inhibitor-1 in chronic kidney disease: evidence and mechanisms of action

GLP-1 receptor agonists like semaglutide and liraglutide work by regulating appetite and glucose metabolism, with no direct effect on spinal or musculoskeletal structures

Liraglutide Attenuates Non-Alcoholic Fatty Liver Disease in Mice by Regulating the Local Renin-Angiotensin System

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A recent meta-analysis conducted on elderly T2D patients (15 studies, n = 11,679) evidenced that a combination of GLP-1RAs with SGLT2is (with an intervention period of at least six months), beyond demonstrating a positive safety profile, gave more benefits over monotherapy in terms of glycemic control, weight management, and CV protection [137]