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Spatial learning and memory were assessed using the Morris Water Maze and Passive Avoidance tests

Clinical trials showed Retatrutide producing an average 24.2% body weight reduction over 48 weeks at the highest dose tested, making it the most effective weight loss compound ever studied in clinical trials

Farnesoid X receptor agonists, such as obeticholic acid, regulate bile acid metabolism, lipid homeostasis, and hepatic inflammation (137)

Semaglutide lowers body weight by reducing appetite and hunger, increasing satiety, reducing food cravings, altering food preferences, and reducing energy intake

Clinical trials reveal an average 15% reduction in body weight over 68 weeks