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Even though it is less consumed, guarana (Paullinia cupana), native to the Amazon rainforest, contains one of the highest natural concentrations of caffeine (2.5% to 8.0% in dry weight) with a chemical profile also rich in phenolic compounds like theobromine, catechins and tannins.2 The tannins help to slow the release of caffeine into the bloodstream, resulting in a more prolonged stimulatory effect.3 This unique pharmacokinetic behavior has led to the widespread incorporation of guarana extract into energy drinks and fatigue-reducing supplements

Given its physiological roles, the GLP-1R is targeted for treatment of type 2 diabetes

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