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Dipeptidyl peptidase-4 inhibitors DPP-4 is a part of the serine protease family that is found in two membrane-bound and soluble forms in various tissues such as the heart, lung, kidney and liver

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Other more seriousthough less commonrisks: pancreatitis, gallbladder disease, changes in thyroid C-cells (in rodents), and rare digestive complications

Some healthcare providers will prescribe Rybelsus off-label for weight loss for patients who meet eligibility

doi:10.1056/NEJMoa2301972 7
