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Based on the characterization of their binding mechanisms, three distinct groups of DPP4 inhibitors have been identified: saxagliptin, alogliptin, and sitagliptin, each representing a different class

Hence, GLP-1RAs can be utilized as an adjunct alongside metformin as a first-line treatment for type 2 DM or, in specific cases, as a preferred therapeutic agent when additional benefits for cardiovascular or renal protection are required [84]

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or if they develop signs of more serious adverse effects such as severe abdominal pain (which may indicate pancreatitis), symptoms of gallbladder disease, visual changes, severe allergic reactions, or symptoms of thyroid nodules

Yao H, Zhang A, Li D, et al