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Description
Lean muscle loss is also common due to rapid weight loss with GLP-1s

The FDA generally clears semaglutide for adults who meet these criteria: A BMI of 30 or greater (Obesity)

However, no clinical trials available to tell us how microdosing GLP-1s affects body weight or disease management

Early DPP4is that also blocked DPP8 and DPP9 exhibited severe toxicity in preclinical animal models [64]

In practice, GLP-1 RAs are usually avoided in patients with a history of pancreatitis, out of caution, since alternative therapies can be chosen
