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During the shortage, clinicians are also required to: Only prescribe GLP-1 RAs for their licensed indication Review the need for prescribing a GLP-1 RA agent and stop treatment if no longer required due to not achieving desired clinical effect as per NICE CG28 Avoid switching between brands of GLP-1 RAs, including between injectable and oral forms Where a higher dose preparation of GLP-1 RA is not available, do not substitute by doubling up a lower dose preparation Where GLP-1 RA therapy is not available, proactively identify patients established on the affected preparation and consider prioritising for review based on the criteria below

Glucagon-like-peptide-1 receptor agonist, like native glucagon-like peptide-1, Exendin-4, and Liraglutide, exert context-, dose-, and timing-dependent effects on human mesenchymal stem cells

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The role of estrogen in insulin resistance: A review of clinical and preclinical data