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10.1136/bmjdrc-2019-000783 185 YangX.QiangQ.LiN.FengP.WeiW.HlscherC

15, the lower the purity of the intermediate, the more impurities are introduced into the intermediate or product, and particularly, the raw material Arg34GLP-1 (9-37) and the double-modified impurity which are difficult to remove are more easily obtained

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18 Although treatments are available for diabetes and obesity, there are multiple long-term complications: they remain the leading causes of cardiovascular disease, eye pathology, lower limb amputation and end-stage renal disease