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Thus, it is argued that therapeutic interventions that target glycemia but do not correct the underlying pathogenic disturbances are unlikely to result in a sustained benefit on the disease process

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The lifestyle interventions should be monitored, adapted, and perpetuated in an informed consent with the patient over the years, regardless of whether additional medical or surgical therapy is started in the course of T2D or obesity (16, 17, 2325)

24 Erdogan et al 192 found that Dapagliflozin decreased seizure activity in rats with pentylenetetrazol (PTZ) but induced epileptic seizure

Furthermore, the administration of Exendin-4 to SOD1 G93A mutant mice via a subcutaneous osmotic pump provides a steady-state infusion, improves glucose tolerance, normalizes running wheel behavior, and attenuates neuronal cell death in the lumbar spinal cord [147]